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KMID : 0361020010440030246
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Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 3 p.246 ~ p.250
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Comparison of early tissue reactions between Plastipore and Polycel in rat middle ear
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Abstract
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Background & Objectives : There has been only a few reports of animal investigation of the fate of otologic polymer. This study was designed for comparing the early tissue reaction of Plastipore and Polycel that have been most commonly used.
Materials &
Methods: Plastipore and Polycel were inserted into middle ear of Sprague Dawley rats. After 1, 2 and 4 weeks, the temporal bones were removed and tissue reactions were observed with Hematoxillin-Eosin stain. Results: More neutrophils were
infiltrated
along the septae of the Plastipore compared with Polycel after 1 week and 2 weeks. Fibrotic changes were found on the surface of Plastipores. After 4 weeks, the tissue reaction of Polycel shows weaker than the Plastipore. It showed that the
Plastipore
had more pronounced and rapid tissue reactions with a thick fibrous encapsulation around it. Conclusion: Plastipore could have relatively worse biocompatibility compared with Polycel.
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KEYWORD
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